Nutraceuticals and nootropics for anti-aging

DMAE is a component of cell membranes and is also one of the substances used by the body to make the cell-signalling molecule acetylcholine. It has been used as a supplement for several decades for a variety of reasons, most of them related to its effects on acetylcholine production in the nervous system or other tissues. (See the discussion on the DMAE page of this website.)

Thanks in part to the efforts of Nicholas Perricone at Michigan State University, DMAE has become well-known as an agent for preventing or reversing age-related wrinkling and creasing of the skin. As result of the popularity of Perricone’s books and his appearances on television, we now have very large numbers of anecdotal reports attesting to the effectiveness of DMAE for reducing these symptoms of skin aging. Fortunately, the evidence does not stop there — at least two convincing clinical studies also support these claims.^1,2

DMAE’s anti-wrinkle effects are thought to involve cell signalling within the skin. Acetylcholine is one of the skin’s signalling molecules, and DMAE may affect its production or its usage.²

Another connection between DMAE and the aging process is suggested by DMAE’s ability to remove deposits of an age-related substance called ‘lipofuscin’.^3,4 Lipofuscin is a brownish conglomerate of fats, metals, and other material that result from an incomplete recycling of biomolecules. It accumulates both inside and outside of cells throughout the body and is considered to be an indicator of age-related damage to cells, or perhaps even a cause of it.^5,6

For use on the skin, DMAE is formulated as a lotion.

DMAE supplements should never be used during pregnancy.

DMAE Serum — don’t use it unless you want your skin to look and feel younger.

DMAE is a component of cell membranes and is also one of the substances used by the body to make the cell-signaling molecule acetylcholine. It has been used as a supplement for several decades for a variety of reasons, most of them related to its effects on acetylcholine production.

Thanks in part to the efforts of Nicholas Perricone at Michigan State University, DMAE has become well-known as an agent for preventing or reversing age-related wrinkling and creasing of the skin. As result of the popularity of Perricone’s books and his appearances on television, we now have very large numbers of anecdotal reports attesting to the effectiveness of DMAE for reducing these symptoms of skin aging. Fortunately, the evidence does not stop there — at least two convincing clinical studies also support these claims.

DMAE’s anti-wrinkle effects may be due, in part, to its ability to remove deposits of an age-related substance called ‘lipofuscin’. Lipofuscin is a brownish conglomerate of fats, metals, and other material that accumulates both inside and outside of cells throughout the body and is considered to be an indicator of age-related damage to cells, or perhaps even a cause of it.

For use on the skin, DMAE-serum is formulated as a lotion.

DMAE supplements should never be used during pregnancy.

For more information on this supplement, click the “Description” tab above.

References

[1] Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res Technol. 2002 Aug;8(3):164-7 Uhoda I, Faska N, Robert C, Cauwenbergh G, Pierard GE.

[2] The role of dimethylaminoethanol in cosmetic dermatology. Am J Clin Dermatol. 2005;6(1):39-47 Grossman R.

[3] Effects of PCA and DMAE on the nematode Caenorhabditis briggsae. Exp Aging Res. 1978 Apr;4(2):133-9 Zuckerman BM, Barrett KA.

[4] Effect of lifetime administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice. Mech Ageing Dev. 1988 Feb;42(2):129-38 Stenback F, Weisburger JH, Williams GM.

[5] Lipofuscin. Int J Biochem Cell Biol. 2004 Aug;36(8):1400-4. Terman A, Brunk UT

[6] Lipofuscin website of Chemistry Department at California State University, Stanislaus Chris Gaugler

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Pronunciation: dimethylaminoethanol 

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— RM

Last modified 2010.08.30

LifeLink’s DMAE Serum is a product of Source Naturals.