Grape seed extract (GSE), from the seeds of red grapes (Vitis vinifera), have a high content of flavonoid compounds known as oligomeric proanthocyanidins (OPCs). OPCs have exceptional antioxidant
properties — they are far more effective than vitamins C or E in reducing free radical and oxidative damage to body tissues.
This suggests that they may be particularly effective in reducing the risk of cancer, cardiovascular disease, and some diseases
associated with aging.
Studies using human breast cancer and lung cancer cells revealed that GSE was able to cause the death of the cancer cells,
while maintaining the growth and viability of the normal cells. In a study of tobacco-induced cell- and DNA-damage, GSE reduced
damage and cell death by as much as 85%.
When GSE was added to human blood plasma, it inhibited the oxidation of LDL — oxidized LDL is a major promoter of atherosclerosis.
GSE’s cardiovascular benefits are considerably enhanced when it is combined with a chromium supplement.
Animal studies suggest that GSE may also be anti-inflammatory, increase circulation (by vasodilation), enhance blood vessel
integrity, and counteract edema.