Product Information

Keywords: minerals, calcium, osteoporosis, psoriasis, multiple sclerosis, retinitis, lupus, phlebitis, obesity, cognition

Calcium Orotate

Calcium orotate is a mineral salt that is normally found in small amounts in all living things. Each molecule of calcium orotate consists of two molecules of orotic acid in which a single calcium atom replaces a pair of hydrogen atoms (one from each orotic acid molecule).

Orotate (orotic acid) is a biochemical substance made by all cells. It is a necessary raw material for making the genetic substances RNA and DNA.4

Calcium is an essential mineral used by the body to make structural material for bones and teeth, and to assist in communications within and between cells.1 The optimum dietary calcium intake for humans ranges from about 400 to 1500 mg/day depending upon age.1,2,3

What we can’t tell you

In the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over the supplement industry and its customers. Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective.

Accordingly, we will limit our discussion of Calcium Orotate to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.

Calcium orotate was introduced as a supplement by Dr. Hans Nieper, the innovative German physician,5 who used it to treat or prevent the following conditions:6,7

  • bone loss and pain due to inflammation or osteoporosis
  • psoriasis
  • lupus erythematosus
  • arthritis and spondylitis
  • high blood pressure
  • angina pectoris
  • multiple sclerosis
  • encephalitis
  • retinitis
  • phlebitis
  • hepatitis, and
  • colitis.

Nieper considered orotates to be superior to carbonates, chlorides, sulfates, and other anions as bioavailability enhancers for minerals like calcium.7

Nieper was a controversial figure whose treatments were denounced by many in the medical profession and were targeted by the U.S. Food and Drug Administration — despite the fact that these critics had done essentially no investigation of these treatments, and despite the fact that countless thousands of Nieper’s patients and followers found the treatments to be superbly effective.5 Nieper died in 1998, but his influence lives on.

Other researchers have also studied some of the medical applications of calcium ororate. Let’s look briefly at these applications.

Bone strength and osteoporosis

Calcium supplements are universally recognized as preventatives for bone loss and osteoporosis.8 While other calcium salts, such as calcium citrate, can effectively inhibit bone loss, Hans Nieper’s studies concluded that calcium orotate supplies the bones with more usable calcium per amount of supplement consumed, and also benefits the user in other ways — such as controlling appetite and suppressing inflammatory conditions.9

The element boron has been shown to be important for preventing calcium loss from bones.13 But dietary boron intakes vary widely among different individuals,15 and average around 2 mg/day14 — whereas 3 to 10 mg/day seems to be indicated for maintaining bones and joints.16 Calcium supplements should therefore include boron to improve the calcium’s bioavailability.

Weight loss

In one of Nieper’s research papers he mentioned having noticed that calcium orotate usage suppresses the appetite of chronic overeaters. Nieper’s observation was explored by science writer Ed Sharpe who found that this supplement, at 745 mg once or twice a day, is an excellent regulator of appetite. “Over a period of months I lost over 25 pounds without dieting in any way. During this time I ate all the food I wanted without counting calories.”9

Cognitive enhancement

Anecdotal reports, such as those of Ed Sharpe, suggest that calcium orotate has mood-elevating, cognitive-enhancing effects which begin about half an hour after taking the supplement and last several hours.9

Inflammatory diseases

Many of the ailments which Hans Nieper treated with calcium orotate are inflammatory in nature. These include psoriasis, lupus, arthritis, spondylitis, various cardiovascular ailments, encephalitis, retinitis, phlebitis, colitis, and multiple sclerosis. This suggests that calcium orotate may be acting as an anti-inflammatory agent and could be helpful for other inflammatory conditions, such as IBS, bursitis, chronic runny nose, diverticulitis, gastritis, laryngitis, otitis, mastitis, pancreatitis, pinkeye, sinusitis, shin splints, tendonitis, vaginitis, and many others. No studies have been done to test this concept but one piece of indirect supporting evidence is the fact that calcium supplements are a proven preventative for colorectal cancer, a well-studied disease in which inflammation plays an important role.10


Are Calcium Orotate supplements useful for the conditions and purposes mentioned above? We aren’t allowed to tell you, so you should take a look at some of the references cited here, and then decide for yourself.

Review articles

For a good introductory discussion of mineral salts and other related mineral transporters, see the review Mineral chelates, salts and colloids by Alvin Hashimoto.11 For an explanation of possible mechanisms through which orotates operate in the body, see the article How orotates work: The biochemistry of ‘vitamin B13’ by Ed Sharpe.12

40105 745 mg 100 tablets 3 tablets $24.65
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Pronunciation: orotic ō·rāʹ·tĭk, orotate orʹ·o·tät

— RM

Last modified 2010.09.01